Aging and Fitness

 


New Research

June 2008 - in the news this month are claims that a chemical in the skin of red grapes will help you live longer.
Dr David Sinclair, Harvard Medical School professor, says the chemical contains a potent anti-ageing compound, called resveratrol.

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April 2008 - Antioxidant warning

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Enteracept and Alzheimer's

A drug, usually used to treat arthritis, has shown dramatic improvement in Alzheimer's patients.
Enteracept, which is given by injection in the neck, seems to improve in memory, the ability to think and calculate and verbal ability.
It works by mopping up the surplus of a chemical called tumour necrosis factor-alpha.
The Alzheimer's Society has called for a full clinical trial.

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Alzheimer's Disease

There is evidence that the cold sore virus may be linked to Alzheimer's disease. In lab tests at Manchester University it was found that brains infected with the herpes simplex virus, HSV-1, saw a rise in a protein linked to Alzheimer's.

Researchers believe the discovery could pave the way for a vaccine that may help prevent the brain disorder but the breakthrough could be a long way off yet.

Cultures of human brain cells were infected with the virus and a "dramatic" increase in levels of the beta amyloid protein were found - these are the building blocks of deposits which form in the brains of people with Alzheimer's.

Previous research has established that HSV-1 is found in the brains of up to 70% of people with Alzheimer's.

A team from the University of Rochester Medical Centre in New York found that HSV-1 was more likely to cause a problem in people who carry a mutant version of a specific gene called ApoE4, which is involved in the breakdown
of fats by the body. They found the vast majority of Alzheimer's patients they examined carried the gene - and suspect that it works to make HSV-1 more active.

Scientists have still to establish a direct link between the virus and the disease, but the Manchester team believe the findings offer hope for the future.

It would appear that Alzheimer's is a multi-factorial disease with many different causes but for some people a mixture of the gene variant and the virus could be contributing to it.

The research continues.

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Heart Disease and Flavinoids

A diet rich in compounds called flavinoids can reduce some of the early signs of heart disease.

A research team from the Institute of Food focused on one of the compounds, quercetin, which is found in tea, onions, apples and red wine.

They particularly wanted to know what happens to quercetin after the body breaks it down and found that the sub-compounds help prevent chronic inflammation, which can lead to thickening of the arteries (atherosclerosis).

A surprise finding was that lower doses could have a bigger impact in reducing some of the inflammatory processes and that eating 100g - 200g of onions per day could have a very beneficial effect.

A nutrition scientist at the British Nutrition Foundation, said: "Inflammation is an important process in the furring up of arteries that can lead to heart disease and stroke and this study gives us clues as to why a diet rich in fruit and vegetables appears to reduce the risk of these conditions".

This research underlines the importance of eating 5 portions of fruit and vegetables per day.

 

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